01/21/2026

Proposed Medicare Drug Pricing Models Aim to Align U.S. Drug in Other Countries

The Centers for Medicare & Medicaid Services released two proposed drug pricing models—Global Benchmark for Efficient Drug Pricing (GLOBE) and Guarding U.S. Medicare Against Rising Drug Costs (GUARD)—intended to reduce Medicare spending by aligning U.S. drug prices with international pricing benchmarks. Both models target high-cost, single-source drugs, which includes many chemotherapy and immunotherapy agents.

The GLOBE Model tests payment reforms on Medicare Part B drugs—typically those administered in a physician's office or hospital outpatient setting.  Read more on ASCO in Action.